Description

Exo-(+)-1R,2R,4S-2-(6-Chloro-3-Pyridinyl)-7-Azabicyclo[2.2.1]Heptane Dihydrochloride is a high-purity, stereochemically defined bicyclic amine derivative, serving as a critical advanced pharmaceutical intermediate and chiral building block for complex organic synthesis. Its precise stereochemistry and functional groups make it invaluable for research and development in medicinal chemistry, particularly for creating novel bioactive molecules. This compound is essential for scientists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for next-generation product development.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and infectious diseases.
• Agrochemical Research: Building block for developing novel insecticides and pesticides, leveraging the 6-chloro-3-pyridinyl moiety.
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and as a scaffold for creating new chemical entities in high-throughput screening libraries.
• Asymmetric Synthesis: Employed as a chiral ligand or auxiliary in catalytic asymmetric reactions to induce stereoselectivity.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and enzyme functions.
• Process Chemistry & Scale-Up: Serves as a validated intermediate for the pilot and commercial-scale manufacturing of complex organic molecules.

Basic Information

Product Name	Exo-(+)-1R,2R,4S-2-(6-Chloro-3-Pyridinyl)-7-Azabicyclo[2.2.1]Heptane Dihydrochloride
CAS No.	166374-43-2
Molecular Formula	C11H14ClN2·2HCl
Molecular Weight	279.06 g/mol (Free base: 206.70 g/mol)
Synonyms	(1R,2R,4S)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride; (exo)-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane dihydrochloride; 7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, hydrochloride (1:2), (1R,2R,4S)-; 166374-43-2; Bicyclo[2.2.1]heptan-2-amine derivative; 6-Chloro-3-pyridinyl substituted norbornane amine salt
EINECS	Contact for details

Quality Control

Our Exo-(+)-1R,2R,4S-2-(6-Chloro-3-Pyridinyl)-7-Azabicyclo[2.2.1]Heptane Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemical configuration, and consistent performance. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with the standards expected for GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (exo, 1R,2R,4S)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.