Description

2-Benzyloxy-5-Iodo-3-Methylpyridine is a high-purity, halogenated pyridine derivative with a benzyl-protected oxygen functionality. This compound serves as a critical synthetic intermediate in advanced organic synthesis, particularly valued for its iodine substituent which enables further cross-coupling reactions. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors or other heterocyclic-based therapeutics.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Negishi couplings to form new carbon-carbon bonds.
• Agrochemical Research: Used in the development and research of new pesticides and herbicides where the pyridine core is a common structural motif.
• Material Science Precursor: Serves as a specialized monomer or precursor for synthesizing functionalized polymers or organic electronic materials.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems due to its modifiable structure.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	2-Benzyloxy-5-Iodo-3-Methylpyridine
CAS No.	166266-20-2
Molecular Formula	C13H12INO
Molecular Weight	325.15 g/mol
Synonyms	5-Iodo-3-methyl-2-(phenylmethoxy)pyridine; 3-Methyl-2-(benzyloxy)-5-iodopyridine; 2-(Benzyloxy)-5-iodo-3-methylpyridine; Pyridine, 2-(benzyloxy)-5-iodo-3-methyl-; 166266-20-2; 5-Iodo-2-benzyloxy-3-methylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Benzyloxy-5-Iodo-3-Methylpyridine is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards, including identity confirmation by spectroscopic methods and purity assessment by HPLC. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.