Description

A-(p-Toluenesulfonyl)-4-Fluorobenzylisonitrile is a specialized organic building block featuring a sulfonyl-protected isonitrile functional group. This compound is valued for its role as a key intermediate in the synthesis of complex heterocycles and bioactive molecules, particularly within pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate unique molecular scaffolds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for targeted therapies.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Chemical Biology Probe Synthesis: Employed in the creation of isonitrile-containing probes for studying biological pathways.
• Heterocyclic Chemistry: Serves as a versatile building block for constructing complex nitrogen-containing ring systems.
• Material Science: Potential intermediate in the development of specialty polymers and functional materials.
• Multicomponent Reaction (MCR) Chemistry: A valuable reactant in Ugi and Passerini-type reactions for rapid library synthesis.

Basic Information

Product Name	A-(p-Toluenesulfonyl)-4-Fluorobenzylisonitrile
CAS No.	165806-95-1
Molecular Formula	C15H12FNO2S
Molecular Weight	289.32 g/mol
Synonyms	4-Fluoro-N-[(isocyanomethyl)sulfonyl]benzenamine; 4-Fluorobenzyl isocyanide p-toluenesulfonate; TosMIC-4-F derivative; 1-Isocyano-1-(4-fluorophenyl)methane p-toluenesulfonyl derivative; (4-Fluorophenyl)(isocyano)methane p-toluenesulfonate; A-(4-Fluorobenzyl)isonitrile p-toluenesulfonyl adduct
EINECS	Contact for details

Quality Control

Our A-(p-Toluenesulfonyl)-4-Fluorobenzylisonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.