Description

3,4,5-Trimethoxybenzylisocyanide is a versatile and highly reactive organic building block, specifically an isocyanide derivative of trimethoxybenzene. Its primary value lies in its role as a critical reactant in multi-component reactions, such as the Ugi and Passerini reactions, enabling the efficient synthesis of complex heterocyclic and peptidomimetic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries engaged in drug discovery, medicinal chemistry, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs) via multicomponent reaction chemistry.
• Medicinal Chemistry & Drug Discovery: Used extensively in high-throughput screening and combinatorial chemistry to generate diverse libraries of compounds for biological evaluation.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides by constructing unique molecular architectures.
• Material Science: Serves as a building block for the synthesis of specialized polymers, ligands, and functional materials.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	3,4,5-Trimethoxybenzylisocyanide
CAS No.	165459-74-5
Molecular Formula	C11H13NO3
Molecular Weight	207.23 g/mol
Synonyms	1-Isocyanomethyl-3,4,5-trimethoxybenzene; (3,4,5-Trimethoxyphenyl)methyl isocyanide; 3,4,5-Trimethoxybenzyl isonitrile; TMBI; TMB-Isocyanide
EINECS	Contact for details

Quality Control

Our 3,4,5-Trimethoxybenzylisocyanide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and absence of critical impurities. We adhere to cGMP standards where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use and stored away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.