Description

(3-Bromo-4-Methylphenoxy)(tert-Butyl)Dimethylsilane is a specialized organosilicon reagent featuring a brominated aromatic moiety protected by a tert-butyldimethylsilyl (TBDMS) ether group. This compound is a critical intermediate in advanced organic synthesis, particularly for the controlled introduction of functionalized phenolic units under mild conditions. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), especially where a bromo-substituted phenol is required for further cross-coupling reactions (e.g., Suzuki, Heck).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the reactivity of the bromine atom for structural diversification.
• Material Science & Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers, liquid crystals, or advanced organic electronic materials.
• Organic Synthesis Reagent: The TBDMS-protected phenol group provides stability during multi-step syntheses, allowing for selective deprotection at a later stage.
• Chemical Research & Development: Essential for academic and industrial R&D labs exploring new synthetic methodologies and creating novel chemical entities for screening.

Basic Information

Product Name	(3-Bromo-4-Methylphenoxy)(tert-Butyl)Dimethylsilane
CAS No.	164513-48-8
Molecular Formula	C13H21BrOSi
Molecular Weight	301.30 g/mol
Synonyms	3-Bromo-4-methylphenoxy-tert-butyldimethylsilane; tert-Butyl(3-bromo-4-methylphenoxy)dimethylsilane; 3-Bromo-4-methylphenyl tert-butyldimethylsilyl ether; TBDMS ether of 3-bromo-4-methylphenol; Silane, (3-bromo-4-methylphenoxy)(1,1-dimethylethyl)dimethyl-; 1-((tert-Butyldimethylsilyl)oxy)-3-bromo-4-methylbenzene; 3-Bromo-p-cresol TBDMS ether
EINECS	Contact for details

Quality Control

Our production of (3-Bromo-4-Methylphenoxy)(tert-Butyl)Dimethylsilane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized using advanced analytical techniques including GC, HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.