Description

(-)-(3S)-3-([tert-Butyl(Dimethyl)Silyl]Oxy)Dihydrofuran-2(3H)-One is a high-value, chiral silyl-protected lactone derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a protected hydroxyl group in a specific stereochemical configuration, enabling the stereoselective synthesis of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for constructing chiral building blocks for active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in stereoselective reactions to introduce chiral centers with high enantiomeric purity.
• Natural Product Synthesis: Facilitates the construction of chiral fragments found in complex natural products.
• Fine Chemical Production: Intermediate in the manufacture of specialty chemicals, agrochemicals, and advanced materials.
• Process Chemistry Development: Employed in route scouting and optimization for scalable manufacturing processes.
• Academic & Industrial R&D: Serves as a versatile reagent for methodological development in organic and medicinal chemistry.

Basic Information

Product Name	(-)-(3S)-3-([tert-Butyl(Dimethyl)Silyl]Oxy)Dihydrofuran-2(3H)-One
CAS No.	164264-14-6
Molecular Formula	C₁₀H₂₀O₃Si
Molecular Weight	216.35 g/mol
Synonyms	(3S)-3-[(tert-Butyldimethylsilyl)oxy]dihydrofuran-2(3H)-one; (-)-3-[(tert-Butyldimethylsilyl)oxy]dihydro-2(3H)-furanone; (S)-3-((tert-Butyldimethylsilyl)oxy)dihydrofuran-2(3H)-one; (S)-3-(TBDMSO)dihydrofuran-2(3H)-one; (S)-3-(tert-Butyldimethylsilyloxy)-γ-butyrolactone; TBDMS-protected (S)-3-hydroxy-γ-butyrolactone; Chiral TBDMS lactone derivative
EINECS	Contact for details

Quality Control

Our (-)-(3S)-3-([tert-Butyldimethylsilyl]oxy)dihydrofuran-2(3H)-one is manufactured under strict quality control protocols to ensure high chemical and chiral purity. Each batch is characterized by advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, potency, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.