Description

(S)-(-)-1-Phenylpropyl Isocyanate is a chiral isocyanate building block of significant importance in asymmetric synthesis. Its value lies in its ability to introduce the (S)-1-phenylpropyl moiety, a key chiral auxiliary and intermediate in the production of enantiomerically pure compounds. This high-purity chiral reagent is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing active ingredients, catalysts, and advanced materials where stereochemical control is critical.

Application

• As a key chiral intermediate in the synthesis of pharmaceutical active ingredients, particularly for central nervous system (CNS) and cardiovascular drugs.
• In the preparation of chiral auxiliaries and ligands for asymmetric catalysis and enantioselective synthesis.
• For the development of advanced agrochemicals, including herbicides and pesticides with specific stereochemical activity.
• In materials science research for creating chiral polymers and liquid crystals with unique optical properties.
• As a derivatization agent in analytical chemistry for the separation and analysis of enantiomers via chromatography.
• For the synthesis of chiral ureas and carbamates, which are important scaffolds in medicinal chemistry.

Basic Information

Product Name	(S)-(-)-1-Phenylpropyl Isocyanate
CAS No.	164033-12-9
Molecular Formula	C10H11NO
Molecular Weight	161.20 g/mol
Synonyms	(S)-1-Phenylpropyl isocyanate; (S)-(-)-α-Methylbenzyl isocyanate; (S)-1-Phenylethyl isocyanate (common misnomer, verify structure); (S)-(-)-1-Phenylethyl isocyanate; (S)-α-Methylbenzyl isocyanate; (S)-1-Phenyl-1-ethyl isocyanate; (S)-PEIC; (S)-MBA-NCO
EINECS	Contact for details

Quality Control

Our (S)-(-)-1-Phenylpropyl Isocyanate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical and enantiomeric purity, meeting the stringent requirements for research and process development. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profile is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.