Description

(R)-1-Phenylpropyl Isocyanate is a chiral isocyanate building block of significant importance in asymmetric synthesis. Its primary value lies in its role as a key intermediate for introducing the (R)-1-phenylpropyl moiety into target molecules, enabling the creation of compounds with specific stereochemistry. This product is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs), chiral ligands, and advanced materials where optical purity is critical.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the production of chiral pesticides, herbicides, and plant growth regulators that require specific stereochemistry for optimal activity.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized chiral ligands and organocatalysts used in asymmetric catalysis.
• Advanced Material Development: Employed in the research and production of specialty polymers and liquid crystals where chiral centers dictate material properties.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CROs/CMOs developing proprietary compounds for clients.
• Academic & Industrial Research: Used in R&D laboratories for methodological studies in organic synthesis and stereochemistry.

Basic Information

Product Name	(R)-1-Phenylpropyl Isocyanate
CAS No.	164033-11-8
Molecular Formula	C10H11NO
Molecular Weight	161.20 g/mol
Synonyms	(R)-1-Phenylethyl Isocyanate; (R)-α-Methylbenzyl Isocyanate; (R)-(-)-1-Phenylethyl Isocyanate; (R)-1-Phenylethylcarbylamine; (R)-PEIC; (R)-MBI; (R)-(-)-Methylbenzyl Isocyanate; (R)-1-Phenyl-1-ethyl Isocyanate
EINECS	Contact for details

Quality Control

Our (R)-1-Phenylpropyl Isocyanate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis (HPLC/GC), to ensure high enantiomeric excess (ee) and chemical purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, assay, impurity profile, and specific rotation. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a recommended temperature of 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and incompatible materials such as alcohols, amines, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.