Description

3-[2-Hydroxy-3-[4-(2-Methoxyethyl)Phenoxy]Propoxy]-1,2-Propanediol 1-(4-Methylbenzenesulfonate) is a high-purity chemical intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters for its role as a key building block in the development of complex active pharmaceutical ingredients (APIs), particularly those targeting cardiovascular and central nervous system disorders. Pharmaceutical manufacturers and advanced R&D laboratories need this material for its precise reactivity and structural features, which enable the construction of sophisticated molecular architectures under controlled conditions.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Cardiovascular Drug Research: Used in the development of β-blockers and other cardiovascular agents due to its specific phenoxypropoxy diol structure.
• Central Nervous System (CNS) Drug Development: Serves as a building block for compounds targeting neurological pathways.
• Chemical Biology Probes: Utilized in the creation of labeled or modified compounds for mechanism-of-action studies.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for efficient commercial-scale API manufacturing.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals for clients.

Basic Information

Product Name	3-[2-Hydroxy-3-[4-(2-Methoxyethyl)Phenoxy]Propoxy]-1,2-Propanediol 1-(4-Methylbenzenesulfonate)
CAS No.	163685-42-5
Molecular Formula	C22H30O9S
Molecular Weight	470.53 g/mol
Synonyms	1,2-Propanediol, 3-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propoxy]-, 1-(4-methylbenzenesulfonate); 3-[2-Hydroxy-3-[4-(2-methoxyethyl)phenoxy]propoxy]-1,2-propanediol 1-tosylate; 1,2-Propanediol, 3-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propoxy]-, 1-(p-toluenesulfonate); 1-Tosyloxy-3-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propoxy]-2-propanol; (2R/S)-1-O-Tosyl-3-O-[2-hydroxy-3-[4-(2-methoxyethyl)phenoxy]propyl]glycerol; Glycerol derivative tosylate; Phenoxypropanediol tosylate intermediate
EINECS	Contact for details

Quality Control

Our 3-[2-Hydroxy-3-[4-(2-Methoxyethyl)Phenoxy]Propoxy]-1,2-Propanediol 1-(4-Methylbenzenesulfonate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity by HPLC, identification by IR/NMR, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed after opening to minimize exposure to atmospheric humidity. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.