Description

Cyclobutanecarboxylic Acid, 1-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester is a high-purity, protected amino acid derivative featuring a cyclobutane ring, a key structural motif in advanced organic synthesis. This compound serves as a critical chiral building block and versatile intermediate for constructing complex molecular architectures. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including peptide mimetics and constrained analogs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in creating conformationally restricted peptides and protease inhibitors.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the cyclobutane core imparts specific biological activity and stability.
• Peptidomimetics & Bioactive Molecules: Essential for constructing peptide analogs with enhanced metabolic stability, bioavailability, and receptor selectivity.
• Chemical Research & Process Development: Employed in academic and industrial laboratories for methodological studies, asymmetric synthesis, and scaling up synthetic routes.
• Material Science Precursor: Potential use as a monomer or building block for specialized polymers and advanced materials with unique structural properties.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 1-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester
CAS No.	163554-54-9
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-[(tert-Butoxycarbonyl)amino]cyclobutanecarboxylic acid ethyl ester; Ethyl 1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylate; Ethyl 1-Boc-aminocyclobutanecarboxylate; Boc-ACBC-OEt; 1-Boc-aminocyclobutanecarboxylic acid ethyl ester; (1-(((tert-Butoxycarbonyl)amino))cyclobutyl)carboxylic acid ethyl ester; 1-Amino-cyclobutanecarboxylic acid ethyl ester, N-Boc-protected
EINECS	Contact for details

Quality Control

Our production of Cyclobutanecarboxylic Acid, 1-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-, Ethyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, and NMR for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation [α]	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.