Description

4-o-Acetyl-3 6-Di-o-(tert-Butyldimethylsilyl)-D-glucal is a key protected carbohydrate intermediate, specifically a tert-butyldimethylsilyl (TBDMS) ether derivative of a glucal sugar. This compound is essential for synthetic chemists as it provides selective protection for hydroxyl groups, enabling complex multi-step synthesis in a controlled manner. It is primarily utilized in the research and development of novel pharmaceuticals, agrochemicals, and advanced materials, where precise stereochemistry and functional group manipulation are critical.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly nucleoside analogs and glycosidase inhibitors.
• Glycochemistry Research: Used in academic and industrial laboratories for the study and synthesis of oligosaccharides, glycoconjugates, and glycomimetics.
• Agrochemical Development: Acts as an intermediate in creating novel pesticides or herbicides with specific sugar-based bioactive moieties.
• Chiral Catalyst & Ligand Synthesis: Provides a chiral scaffold for the development of asymmetric catalysts and ligands used in enantioselective reactions.
• Material Science: Potential use in creating functionalized polymers or surface coatings with specific carbohydrate-based properties.
• Diagnostic Reagent Precursor: Can be used in the development of labeled probes or contrast agents for medical diagnostics.

Basic Information

Product Name	4-o-Acetyl-3 6-Di-o-(tert-Butyldimethylsilyl)-D-glucal
CAS No.	163381-38-2
Molecular Formula	C22H44O6Si2
Molecular Weight	460.76 g/mol
Synonyms	4-O-Acetyl-3,6-di-O-(tert-butyldimethylsilyl)-D-glucal; 3,6-Di-O-(tert-butyldimethylsilyl)-4-O-acetyl-D-glucal; D-Glucal, 4-O-acetyl-3,6-di-O-[(1,1-dimethylethyl)dimethylsilyl]-; 4-Acetyl-3,6-bis-O-(tert-butyldimethylsilyl)-D-glucal; TBDMS-protected glucal acetate; 1,5-Anhydro-4-O-acetyl-3,6-di-O-[(tert-butyldimethylsilyl)]-2-deoxy-D-arabino-hex-1-enitol
EINECS	Contact for details

Quality Control

Our 4-o-Acetyl-3 6-Di-o-(tert-Butyldimethylsilyl)-D-glucal is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.