Description

3-(Triisopropylsilyl)Propiolaldehyde is a highly versatile organosilicon-protected alkyne building block, essential for advanced organic synthesis. Its core value lies in the triisopropylsilyl (TIPS) group, which provides exceptional steric protection for the reactive alkyne and aldehyde functionalities, enabling precise and selective chemical transformations. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures, including natural products and novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of complex drug candidates, particularly in Sonogashira coupling and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel active ingredients with alkyne and aldehyde-derived functional groups.
• Materials Science Precursor: Serves as a monomer or cross-linking agent for creating specialized polymers, conductive materials, and metal-organic frameworks (MOFs).
• Natural Product Synthesis: Employed in the total synthesis of natural products requiring protected alkyne-aldehyde units for macrocyclization or fragment coupling.
• Chemical Biology Probes: Utilized in click chemistry applications (e.g., with azides) to create bioconjugates, fluorescent tags, and activity-based probes.
• Academic & R&D: A fundamental reagent for methodological development in organic chemistry, exploring new catalytic cycles and reaction pathways.

Basic Information

Product Name	3-(Triisopropylsilyl)Propiolaldehyde
CAS No.	163271-80-5
Molecular Formula	C13H24OSi
Molecular Weight	224.42 g/mol
Synonyms	Propiolaldehyde, 3-(triisopropylsilyl)-; TIPS-Propiolaldehyde; 3-(Triisopropylsilyl)prop-2-ynal; (Triisopropylsilyl)propiolaldehyde; 2-Propynal, 3-(triisopropylsilyl)-; 3-(Triisopropylsilyl)-2-propynal; TIPS-protected propiolaldehyde
EINECS	Contact for details

Quality Control

Our 3-(Triisopropylsilyl)Propiolaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.