Description

Fmoc-4-Azido-L-Phenylalanine CAS NO 163217-43-4 is a specialized, non-canonical amino acid derivative designed for advanced bioconjugation and peptide synthesis. This compound is critically important for introducing bioorthogonal azide functional groups into peptides and proteins, enabling subsequent click chemistry reactions for labeling, crosslinking, and drug delivery applications. It is an essential building block for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and chemical biology.

Application

• Peptide Synthesis: As an Fmoc-protected amino acid for solid-phase peptide synthesis (SPPS) to incorporate azide handles into peptide sequences.
• Bioconjugation & Labeling: Enables site-specific modification of peptides and proteins via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) click chemistry.
• Chemical Biology Probes: Used to synthesize activity-based probes (ABPs) and photoaffinity labels for target identification and protein interaction studies.
• Antibody-Drug Conjugate (ADC) Development: Facilitates the construction of stable, defined linker-payload systems for next-generation ADCs.
• Materials Science: Functionalization of surfaces and polymers with bioactive peptides for creating smart biomaterials.
• Glycopeptide Mimetics: Serves as a key intermediate in the synthesis of glycopeptide and glycoprotein mimetics for immunological research.

Basic Information

Product Name	Fmoc-4-Azido-L-Phenylalanine
CAS No.	163217-43-4
Molecular Formula	C24H20N4O4
Molecular Weight	428.44 g/mol
Synonyms	Fmoc-L-4-Azidophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-azido-L-phenylalanine; Fmoc-4-N3-Phe-OH; (2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(4-azidophenyl)propanoic acid; Fmoc-Phe(4-N3)-OH; 4-Azido-L-phenylalanine, N-Fmoc derivative; Fmoc-4-Azido-L-Phe
EINECS	Contact for details

Quality Control

Our Fmoc-4-Azido-L-Phenylalanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere (argon or nitrogen) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.