Description

2-(tert-Butyldimethylsilyloxy)-n-Methoxy-n-Methylacetamide CAS NO 163089-34-7 is a specialized organosilicon-protected intermediate of significant value in advanced organic synthesis. Its core utility lies in its role as a versatile building block for constructing complex molecules, offering chemists a handle for selective deprotection and further functionalization. This compound is primarily needed by research and development laboratories, as well as production facilities, in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of complex drug candidates, particularly in medicinal chemistry research.
• Peptide & Carbohydrate Chemistry: Used for the temporary protection of hydroxyl groups during the synthesis of sensitive peptides, oligosaccharides, and natural products.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides, herbicides, and plant growth regulators.
• Material Science Research: Employed in the creation of novel silicon-containing polymers, dendrimers, and functionalized surfaces.
• Process Chemistry & Scale-Up: Utilized in route development and optimization for the commercial production of high-value specialty chemicals.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new chemical transformations in synthetic organic chemistry.

Basic Information

Product Name	2-(tert-Butyldimethylsilyloxy)-n-Methoxy-n-Methylacetamide
CAS No.	163089-34-7
Molecular Formula	C10H23NO3Si
Molecular Weight	233.39 g/mol
Synonyms	N-Methoxy-N-methyl-2-[(2-methylpropan-2-yl)dimethylsilyl]oxyacetamide; 2-[(tert-Butyldimethylsilyl)oxy]-N-methoxy-N-methylacetamide; Acetamide, 2-[(1,1-dimethylethyl)dimethylsilyl]oxy-N-methoxy-N-methyl-; TBDMS-protected Weinreb amide of glycolic acid; Glycolic acid TBDMS ether N-methoxy-N-methylamide; N-Methoxy-N-methyl-2-((tert-butyldimethylsilyl)oxy)acetamide; 2-(tert-Butyldimethylsiloxy)-N-methoxy-N-methylacetamide
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyldimethylsilyloxy)-n-Methoxy-n-Methylacetamide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.