Description

(4R)-n-(tert-Butyldimethylsilyl)Azetidin-2-One-4-Carboxylic Acid is a high-value, chiral β-lactam derivative and a key protected intermediate in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise stereochemical control, which is critical for developing active pharmaceutical ingredients (APIs). Pharmaceutical research and fine chemical manufacturers need this building block for the synthesis of novel antibiotics, enzyme inhibitors, and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of β-lactam antibiotics and other API candidates.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting specific enzymes.
• Peptidomimetic Chemistry: Serves as a constrained scaffold to mimic peptide structures in drug discovery.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (4R) configuration into target molecules.
• Custom Synthesis & Contract Manufacturing: A specialized building block for custom chemical synthesis services.
• Academic & Industrial R&D: Used in research laboratories for methodological development and exploring new chemical entities.

Basic Information

Product Name	(4R)-n-(tert-Butyldimethylsilyl)Azetidin-2-One-4-Carboxylic Acid
CAS No.	162856-35-1
Molecular Formula	C12H23NO3Si
Molecular Weight	257.40 g/mol
Synonyms	(4R)-1-[(tert-Butyldimethylsilyl)]-2-azetidinone-4-carboxylic acid; (4R)-1-(tert-Butyldimethylsilyl)-2-oxoazetidine-4-carboxylic acid; (4R)-N-(TBDMS)-azetidin-2-one-4-carboxylic acid; (4R)-1-(TBDMS)azetidin-2-one-4-carboxylic acid; TBDMS-protected (R)-3-aminobutanoic acid β-lactam; (R)-1-(tert-Butyldimethylsilyl)-2-azetidinone-4-carboxylic acid; 4-Carboxy-1-(tert-butyldimethylsilyl)azetidin-2-one, (4R)-; 162856-35-1
EINECS	Contact for details

Quality Control

Our (4R)-n-(tert-Butyldimethylsilyl)Azetidin-2-One-4-Carboxylic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing chiral purity, chemical purity, and impurity profiles. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.