Description

Fmoc-Photo-Linker CAS NO 162827-98-7 is a specialized, light-sensitive chemical building block designed for photolabile protection in solid-phase peptide synthesis (SPPS). Its core value lies in enabling the controlled, light-induced cleavage of synthesized peptides from the resin, a critical step for producing high-purity, sensitive biomolecules. This linker is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic laboratories developing peptide-based therapeutics, diagnostics, and probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as a photolabile linker for the attachment and subsequent UV-light-mediated cleavage of peptides from synthesis resins.
• Combinatorial Chemistry: Facilitating the parallel synthesis of peptide libraries where controlled, orthogonal deprotection is required.
• Bioconjugation: Serving as a key intermediate for creating photo-cleavable bioconjugates, affinity tags, and surface-immobilized biomolecules.
• Protecting Group Strategy: Employed in complex multi-step organic syntheses where a light-sensitive protecting group for amines or carboxylic acids is needed.
• Material Science: Used in the development of smart materials and surfaces where light-triggered release of functional molecules is desired.
• Prodrug Development: A component in the design of light-activated prodrugs and drug delivery systems for targeted therapy.

Basic Information

Product Name	Fmoc-Photo-Linker
CAS No.	162827-98-7
Molecular Formula	C24H19NO5
Molecular Weight	401.41 g/mol
Synonyms	Fmoc-Photolabile Linker; 9-Fluorenylmethyl N-(2-Nitro-4-[[(2-nitrophenyl)methoxy]carbonyl]benzyl)carbamate; Fmoc-NVOC Linker; NVOC-Fmoc Linker; Photocleavable Fmoc Linker; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(2-nitrophenyl)propanoic Acid 4-[[(2-Nitrophenyl)methoxy]carbonyl]benzyl Ester; α-Fmoc-3-(2-nitrophenyl)-alanine 4-[[(2-nitrophenyl)methoxy]carbonyl]benzyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Photo-Linker is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.