Description

11-Azaartemisinin is a synthetic derivative of the natural sesquiterpene lactone artemisinin, featuring a nitrogen atom substitution in its core structure. This modification is of significant interest in medicinal chemistry for the development of novel antimalarial and potential anticancer agents, offering a platform for enhanced pharmacokinetic properties and reduced drug resistance. It is a critical advanced intermediate for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of next-generation therapeutic compounds.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of novel artemisinin-derived compounds with potential antimalarial, anticancer, or antiviral activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of heteroatom substitution on the biological activity and metabolic stability of artemisinin analogs.
• Antiparasitic Drug Development: A pivotal precursor in R&D programs aimed at creating new artemisinin-based combination therapies (ACTs) to combat drug-resistant malaria strains.
• Academic & Institutional Research: Employed in universities and research institutes for biochemical studies and the investigation of new therapeutic mechanisms.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing high-value, specialized chemical entities.

Basic Information

Product Name	11-Azaartemisinin
CAS No.	162791-23-3
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	11-Aza-artemisinin; 11-Aza-dihydroartemisinin; 10-Desmethyl-11-azaartemisinin; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyl-1,2,4,5,5a,6,7,8,8a,9,10,12a-dodecahydro-3,10-epoxy[1,2]dioxepino[4,3-i]isochromen-12-ol; Artemisinin, 11-aza-; 11-Aza-DHA
EINECS	Contact for details

Quality Control

Our 11-Azaartemisinin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the exacting standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.