Description

Methyl 2-Azetidinecarboxylate Hydrochloride is a high-purity organic salt, serving as a critical building block in advanced synthetic chemistry. Its value lies in providing a protected azetidine carboxylic acid derivative, essential for constructing complex molecular architectures with high precision. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals, where its unique four-membered ring structure is leveraged.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Protease Inhibitor Research: Used in the development of inhibitors for various proteolytic enzymes due to the azetidine scaffold's conformational constraints.
• Peptidomimetic Chemistry: Employed to introduce constrained amino acid analogs into peptide chains to enhance stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.
• Agrochemical Research: Acts as an intermediate in the development of new herbicides and pesticides with novel modes of action.

Basic Information

Product Name	Methyl 2-Azetidinecarboxylate Hydrochloride
CAS No.	162698-26-2
Molecular Formula	C5H10ClNO2
Molecular Weight	151.59 g/mol
Synonyms	Methyl Azetidine-2-carboxylate Hydrochloride; 2-Azetidinecarboxylic Acid, Methyl Ester, Hydrochloride; Methyl 2-Azetidinecarboxylate HCl; Azetidine-2-carboxylic Acid Methyl Ester Hydrochloride; 1-Azacyclobutane-2-carboxylic Acid, Methyl Ester, Hydrochloride; Methyl (2R)-Azetidine-2-carboxylate Hydrochloride (for enantiopure form); Methyl (2S)-Azetidine-2-carboxylate Hydrochloride (for enantiopure form)
EINECS	Contact for details

Quality Control

Our Methyl 2-Azetidinecarboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.