Description

N(Alpha)-Boc-o-(Dimethylphospho)-L-Threo is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. This compound serves as a critical phosphopeptide building block, enabling the controlled introduction of phosphothreonine mimetics into complex molecular architectures. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel therapeutics, particularly in the areas of signal transduction and kinase inhibitor studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key phosphonylated building block for the automated synthesis of phosphopeptides and their analogs.
• Medicinal Chemistry & Drug Discovery: Used in the design and synthesis of potential kinase inhibitors and modulators of protein-protein interactions.
• Bioconjugation & Probe Development: Facilitates the creation of labeled peptides for biochemical assays, imaging, and diagnostic applications.
• Chemical Biology Research: Enables the study of phosphorylation-dependent processes by incorporating stable phosphonate mimics into peptides and proteins.
• Process Development & Scale-Up: Serves as an intermediate in the GMP-compliant production of active pharmaceutical ingredients (APIs) for clinical trials.

Basic Information

Product Name	N(Alpha)-Boc-o-(Dimethylphospho)-L-Threo
CAS No.	162554-18-9
Molecular Formula	C11H22NO7P
Molecular Weight	311.27 g/mol
Synonyms	Boc-Thr(PO(OMe)2)-OH; (2S,3R)-3-[(Dimethoxyphosphoryl)oxy]-2-[(tert-butoxycarbonyl)amino]butanoic acid; N-tert-Butoxycarbonyl-O-(dimethylphosphono)-L-threonine; Boc-L-Threonine(O-dimethylphosphonate); Boc-Thr(OP(O)(OMe)2)-OH; Fmoc-Thr(PO(OMe)2)-OH precursor; Phosphothreonine derivative; Protected phosphoamino acid
EINECS	Contact for details

Quality Control

Our N(Alpha)-Boc-o-(Dimethylphospho)-L-Threo is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material for pre-clinical and clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.