Description

Carbamic Acid, [(1R)-1-(Hydroxymethyl)-2-Propynyl]-, 1,1-Dimethylethyl Ester is a chiral, optically active building block featuring both a carbamate protecting group and a propargyl alcohol moiety. This compound is of significant value in advanced organic synthesis, particularly for the construction of complex molecules where stereochemical control is paramount. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, enabling the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in neurologic and antiviral drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced, stereoselective pesticides and herbicides.
• Peptide Mimetics & PROTACs: The propargyl group enables click chemistry applications for constructing peptide-like structures and proteolysis-targeting chimeras.
• Material Science Research: Acts as a monomer or cross-linker precursor for developing specialty polymers with tailored properties.
• Asymmetric Catalysis Ligand Precursor: The chiral backbone can be utilized to develop novel ligands for asymmetric synthesis.
• Bioconjugation Chemistry: The alkyne functionality allows for efficient, bio-orthogonal conjugation with azide-containing molecules.

Basic Information

Product Name	Carbamic Acid, [(1R)-1-(Hydroxymethyl)-2-Propynyl]-, 1,1-Dimethylethyl Ester
CAS No.	162107-49-5
Molecular Formula	C9H15NO3
Molecular Weight	185.22 g/mol
Synonyms	(R)-tert-Butyl (3-hydroxybut-1-yn-1-yl)carbamate; (R)-N-Boc-3-butyn-2-ol; (1R)-1-(Hydroxymethyl)-2-propynyl carbamic acid tert-butyl ester; tert-Butyl N-[(1R)-1-(hydroxymethyl)prop-2-yn-1-yl]carbamate; (R)-tert-Butyl (1-hydroxy-3-butyn-2-yl)carbamate; Boc-D-propargylglycinol; (R)-Boc-Propargyl Alcohol
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1R)-1-(Hydroxymethyl)-2-Propynyl]-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems. Every batch is characterized and tested to ensure high chemical purity and enantiomeric excess (e.e.), critical for chiral applications. Comprehensive analytical methods including HPLC, GC, and chiral chromatography are employed. Certificates of Analysis (COA) detailing identity, purity, and specific rotation are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% e.e.
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.