Description

Spiro[Bicyclo[3.1.0]Hexane-2,2-[1,3]Dioxolane]-1-Methanol (9Ci) is a specialized spirocyclic organic compound featuring a fused bicyclo[3.1.0]hexane and dioxolane ring system with a pendant methanol group. This unique molecular architecture makes it a valuable and versatile advanced pharmaceutical intermediate and chiral building block for complex organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries to construct novel molecular scaffolds with potential biological activity. The compound, identified by CAS No. 161794-35-0, is supplied under stringent quality control to ensure batch-to-batch consistency for critical research and manufacturing processes.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis Building Block: Utilized in stereoselective reactions to introduce complex, rigid spirocyclic motifs into target molecules, enhancing their three-dimensional diversity.
• Ligand and Catalyst Development: Acts as a scaffold for creating novel chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the discovery and development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Investigated as a monomer or cross-linking agent for producing polymers with unique thermal and mechanical properties.
• Academic and Industrial R&D: Used in methodological studies and the exploration of new chemical spaces for drug discovery and chemical biology.

Basic Information

Product Name	Spiro[Bicyclo[3.1.0]Hexane-2,2-[1,3]Dioxolane]-1-Methanol (9Ci)
CAS No.	161794-35-0
Molecular Formula	C9H14O3
Molecular Weight	170.21 g/mol
Synonyms	1-(Hydroxymethyl)spiro[bicyclo[3.1.0]hexane-2,2'-[1,3]dioxolane]; Spiro(bicyclo[3.1.0]hexane-2,2'-[1,3]dioxolane)-1-methanol; 1-Methylolspiro(bicyclo[3.1.0]hexane-2,2'-[1,3]dioxolane); (1S,5R)-3-Oxabicyclo[3.1.0]hexane-2,2-diyl)dimethanol (related isomer); Spirocyclic dioxolane methanol derivative; Bicyclo[3.1.0]hexane spirodioxolane methanol.
EINECS	Contact for details

Quality Control

Every batch of Spiro[Bicyclo[3.1.0]Hexane-2,2-[1,3]Dioxolane]-1-Methanol (9Ci) is produced and analyzed under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade and custom synthesis specifications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Specific Rotation (Optical Purity)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.