Description

Daniplestim CAS NO 161753-30-6 is a synthetic cytokine receptor agonist, specifically a potent and selective stimulator of thrombopoietin (TPO) receptor activity. This compound is of significant interest in pharmaceutical research and development for its potential to stimulate platelet production. It is primarily utilized by researchers and developers in the biopharmaceutical industry focusing on hematology, oncology, and the treatment of thrombocytopenia.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel thrombopoietin receptor agonists for clinical development.
• Biomedical Research: Used as a reference standard or active agent in in vitro and in vivo studies to investigate megakaryocytopoiesis and platelet biology.
• Preclinical Development: Employed in the formulation and efficacy testing of potential therapeutic candidates for conditions like chemotherapy-induced thrombocytopenia.
• Cell Culture & Differentiation: Applied in stem cell research to promote the differentiation of hematopoietic stem cells into megakaryocytes.
• Assay Development: Utilized in the development and validation of high-throughput screening assays for TPO receptor activity.

Basic Information

Product Name	Daniplestim
CAS No.	161753-30-6
Molecular Formula	C23H29N5O4S
Molecular Weight	471.57 g/mol
Synonyms	Daniplestim; Promegapoietin; Recombinant human promegapoietin; rHuPMP; SC-68420; Thrombopoietin receptor agonist; PEG-rHuMGDF (related conjugate); c-mpl ligand agonist
EINECS	Contact for details

Quality Control

Our Daniplestim is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets rigorous standards suitable for research and development. A detailed Certificate of Analysis (COA) documenting purity, potency, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Potency (Cell-based assay)	Reported per COA
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity	Stimulates TPO-dependent cell proliferation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.