Description

Fmoc-(S)-3-Amino-4-Hydroxybutanoic Acid T-Butyl Ester is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical chiral building block, enabling the precise construction of complex peptide sequences with defined stereochemistry. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential addition of amino acids, particularly where the side-chain hydroxyl group requires protection.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, hormone analogs, and diagnostic agents.
• Synthesis of Bioactive Peptides: Enables the production of peptides with specific biological activities for biochemical and pharmacological studies.
• Peptidomimetic Design: Acts as a scaffold for creating non-peptide compounds that mimic the structure and function of natural peptides.
• Combinatorial Chemistry Libraries: Employed in generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Item	Details
Product Name	Fmoc-(S)-3-Amino-4-Hydroxybutanoic Acid T-Butyl Ester
CAS No.	161529-14-2
Molecular Formula	C23H27NO6
Molecular Weight	413.47 g/mol
Synonyms	Fmoc-AHPB-OtBu; Fmoc-(S)-3-Amino-4-hydroxybutyric acid tert-butyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-hydroxybutanoic acid 1,1-dimethylethyl ester; (S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-hydroxybutanoic acid tert-butyl ester; tert-Butyl (S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-hydroxybutanoate; Fmoc-3-Ahob-OtBu; Fmoc-Ahob(OtBu)-OH; Protected AHPB derivative
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-4-Hydroxybutanoic Acid T-Butyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive pharmaceutical research. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral purity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.