Description

7-Oxa-3-Azabicyclo[4.1.0]Heptane-3-Carboxylic Acid, 1,1-Dimethylethyl Ester is a high-value, protected bicyclic amino acid derivative, specifically a tert-butyl ester of a constrained aziridine-fused morpholine scaffold. This compound serves as a critical chiral building block and advanced pharmaceutical intermediate, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, enzyme modulators, and other bioactive molecules requiring a rigid, nitrogen-oxygen containing bicyclic structure.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides where the unique aziridine-morpholine core can impart specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics and Conformationally Restricted Peptides: Incorporated into peptide backbones to induce specific secondary structures and enhance metabolic stability for drug discovery programs.
• Academic and Industrial R&D: A valuable tool for medicinal chemists and synthetic organic chemists exploring new reaction methodologies and compound libraries.
• Material Science Research: Potential monomer or building block for specialty polymers with unique properties derived from its strained ring system.

Basic Information

Product Name	7-Oxa-3-Azabicyclo[4.1.0]Heptane-3-Carboxylic Acid, 1,1-Dimethylethyl Ester
CAS No.	161157-50-2
Molecular Formula	C10H17NO3
Molecular Weight	199.25 g/mol
Synonyms	tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate; 3-(tert-Butoxycarbonyl)-3-aza-7-oxabicyclo[4.1.0]heptane; 3-Boc-3-aza-7-oxabicyclo[4.1.0]heptane; 3-Aza-7-oxabicyclo[4.1.0]heptane-3-carboxylic acid tert-butyl ester; Bicyclo[4.1.0]heptane, 7-oxa-3-aza-, 3-carboxylic acid, 1,1-dimethylethyl ester; Aziridino-tetrahydro-1,4-oxazine tert-butyl ester; Protected aziridine-morpholine derivative
EINECS	Contact for details

Quality Control

Our production of 7-Oxa-3-Azabicyclo[4.1.0]Heptane-3-Carboxylic Acid, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the exacting standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity	≥ 99.0% ee (by Chiral HPLC)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.