Description

(R)-Piperidine-1,3-Dicarboxylic Acid 1-Benzyl Ester is a high-purity chiral building block of significant importance in advanced organic synthesis. Its value lies in its defined stereochemistry and functional groups, which make it a critical intermediate for constructing complex molecular architectures. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Asymmetric Synthesis: Serves as a versatile precursor for the construction of piperidine-based scaffolds and other nitrogen-containing heterocycles via stereoselective reactions.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents and pesticides that require specific stereochemistry for optimal activity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for use in enantioselective catalysis.
• Chemical Biology & Proteomics: Acts as a building block for designing molecular probes, enzyme inhibitors, and other tools for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity chiral intermediates.

Basic Information

Product Name	(R)-Piperidine-1,3-Dicarboxylic Acid 1-Benzyl Ester
CAS No.	160706-62-7
Molecular Formula	C15H19NO4
Molecular Weight	277.32 g/mol
Synonyms	(3R)-1-(Benzyloxycarbonyl)piperidine-3-carboxylic acid; (R)-1-Benzyl 3-carboxypiperidine-1,3-dicarboxylate; (R)-1-CBZ-3-carboxypiperidine; (R)-1-Benzyloxycarbonylpiperidine-3-carboxylic Acid; (R)-N-CBZ-Nipecotic Acid; (R)-1-N-Carbobenzyloxynipecotic Acid; (R)-Piperidine-1,3-dicarboxylic acid 1-benzyl ester; (R)-1,3-Piperidinedicarboxylic acid, 1-(phenylmethyl) ester
EINECS	Contact for details

Quality Control

Our (R)-Piperidine-1,3-Dicarboxylic Acid 1-Benzyl Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.