Description

(Iodoethynyl)Triisopropylsilane is a highly versatile organosilicon reagent featuring a reactive iodoethynyl group protected by a bulky triisopropylsilyl (TIPS) moiety. This compound is critical for advanced organic synthesis, particularly in cross-coupling and alkyne functionalization reactions, where it serves as a stable yet reactive building block. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex molecules via Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used to introduce acetylene units into novel pesticide and herbicide candidates for structure-activity relationship (SAR) studies.
• Materials Science: Serves as a precursor for functionalized polymers, dendrimers, and molecular wires in electronic and optoelectronic materials.
• Chemical Biology: Employed as a bio-conjugation reagent for labeling biomolecules (proteins, nucleic acids) via click chemistry and other alkyne-based reactions.
• Organic Synthesis Building Block: Provides a protected acetylene equivalent for the controlled, sequential elaboration of complex organic frameworks in total synthesis.
• Catalyst & Ligand Development: Used in the preparation of novel organometallic catalysts and ligands for asymmetric synthesis.

Basic Information

Product Name	(Iodoethynyl)Triisopropylsilane
CAS No.	160481-43-6
Molecular Formula	C11H21ISi
Molecular Weight	308.28 g/mol
Synonyms	Triisopropyl(iodoethynyl)silane; (Iodoethynyl)triisopropylsilane; 1-Iodo-2-(triisopropylsilyl)acetylene; TIPS-Iodoacetylene; (Triisopropylsilyl)iodoacetylene; Iodotriisopropylsilylacetylene; 160481-43-6; Acetylene, [iodo(triisopropylsilyl)]-
EINECS	Contact for details

Quality Control

Our (Iodoethynyl)Triisopropylsilane is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system supports compliance with global regulatory standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.