Description

4-(Triethylsilyl)-3-Butyn-1-Ol is a versatile organosilicon building block featuring both a terminal alkyne and a protected alcohol functional group. This bifunctional nature makes it a critical intermediate for constructing complex molecular architectures in advanced organic synthesis. It is particularly valuable for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require high-purity, reliable intermediates for coupling reactions and polymer synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that incorporate silicon and alkyne moieties.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers, dendrimers, and silicon-based hybrid materials.
• Liquid Crystal & OLED Materials: A precursor in the synthesis of advanced organic electronic materials requiring precise molecular alignment and electronic properties.
• Protecting Group Strategy: The triethylsilyl (TES) group protects the alkyne, allowing for selective functionalization at the alcohol site in multi-step syntheses.
• Click Chemistry: The terminal alkyne is amenable to copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and labeling applications.

Basic Information

Product Name	4-(Triethylsilyl)-3-Butyn-1-Ol
CAS No.	160194-29-6
Molecular Formula	C10H20OSi
Molecular Weight	184.35 g/mol
Synonyms	3-Butyn-1-ol, 4-(triethylsilyl)-; 4-(Triethylsilyl)but-3-yn-1-ol; 4-Triethylsilyl-3-butyn-1-ol; (4-Hydroxybut-1-yn-1-yl)triethylsilane; TES-Protected Butynol; Triethyl(4-hydroxybut-1-yn-1-yl)silane; 1-Triethylsilyl-3-butyn-1-ol (common misnomer); 4-(Triethylsilyl)butynol
EINECS	Contact for details

Quality Control

Our 4-(Triethylsilyl)-3-Butyn-1-Ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process-scale applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, identity, and moisture content. Our quality systems support compliance with cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.450 - 1.460
Density (g/mL at 20°C)	0.88 - 0.92

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.