Description

[R-(E)]-2-(3-Ethoxy-3-Oxo-1-Propenyl)-1-Piperidinecarboxylic Acid Phenylmethyl Ester is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its defined stereochemistry and functional groups make it a valuable building block for constructing complex molecules with specific biological activity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) targets.
• Asymmetric Synthesis: Used as a precursor or reagent in stereoselective chemical reactions to introduce specific chiral centers into target molecules.
• Medicinal Chemistry Research: Serves as a scaffold or building block for creating compound libraries in drug discovery programs.
• Process Chemistry Development: Employed in optimizing synthetic routes for the scalable production of candidate drugs.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals requiring high enantiomeric purity.
• Academic Research: Applied in university and institutional labs for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	[R-(E)]-2-(3-Ethoxy-3-Oxo-1-Propenyl)-1-Piperidinecarboxylic Acid Phenylmethyl Ester
CAS No.	160169-47-1
Molecular Formula	C18H23NO4
Molecular Weight	317.38 g/mol
Synonyms	(R,E)-Benzyl 2-(3-ethoxy-3-oxoprop-1-en-1-yl)piperidine-1-carboxylate; (R)-Benzyl 2-[(1E)-3-ethoxy-3-oxo-1-propen-1-yl]-1-piperidinecarboxylate; (R,E)-1-Benzyloxycarbonyl-2-(3-ethoxycarbonyl-1-propenyl)piperidine; (R)-1-CBZ-2-[(E)-3-Ethoxycarbonyl-1-propenyl]piperidine; (R,E)-CBZ-Piperidine-2-acrylic acid ethyl ester; (R,E)-N-CBZ-2-(3-Ethoxy-3-oxo-1-propenyl)piperidine
EINECS	Contact for details

Quality Control

Our production of [R-(E)]-2-(3-Ethoxy-3-Oxo-1-Propenyl)-1-Piperidinecarboxylic Acid Phenylmethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is fully characterized and tested against rigorous in-house specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.