Description

3-((tert-Butyldiphenylsilyl)Oxy)-2,2-Difluoropropyl Trifluoromethanesulfonate is a high-value, multi-functional organosilicon reagent and fluorinated building block. This compound is critical for advanced organic synthesis, particularly in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for introducing protected hydroxyl and difluoromethylene groups. It is primarily used by research chemists and process development scientists working on nucleoside analogs, bioactive molecules, and complex natural product synthesis that require precise stereochemical control and fluorination.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antiviral and anticancer nucleoside analogs, where the silyl-protected hydroxyl and triflate leaving group enable selective glycosylation and chain elongation.
• Agrochemical Synthesis: Used to construct difluoromethyl ether and difluoromethylene-containing scaffolds in modern pesticides and herbicides, enhancing their metabolic stability and bioavailability.
• Fluorinated Building Block: Serves as a versatile precursor for introducing the -CH(CF2)OTf moiety into complex molecules via cross-coupling reactions (e.g., Suzuki, Negishi) or nucleophilic substitution.
• Protecting Group Strategy: The tert-butyldiphenylsilyl (TBDPS) group provides robust protection for primary alcohols in multi-step synthetic sequences, which can be selectively deprotected under mild conditions.
• Material Science Research: Employed in the development of fluorinated polymers and specialty materials with unique surface properties and chemical resistance.
• Process Chemistry & Scale-up: Suitable for use in kilogram-scale GMP manufacturing for clinical trial material production, given appropriate quality controls.

Basic Information

Product Name	3-((tert-Butyldiphenylsilyl)Oxy)-2,2-Difluoropropyl Trifluoromethanesulfonate
CAS No.	160052-43-7
Molecular Formula	C20H23F5O4SSi
Molecular Weight	482.54 g/mol
Synonyms	1-(((tert-Butyldiphenylsilyl)oxy)-3,3-difluoropropan-2-yl Trifluoromethanesulfonate; 2,2-Difluoro-3-((tert-butyldiphenylsilyl)oxy)propyl Triflate; 3,3-Difluoro-2-((tert-butyldiphenylsilyl)oxy)propyl Trifluoromethanesulfonate; TBDPS-protected Difluoropropyl Triflate; (3-((tert-Butyldiphenylsilyl)oxy)-2,2-difluoropropyl) Trifluoromethanesulfonate; 160052-43-7; tert-Butyl(2,2-difluoro-3-(trifluoromethanesulfonyloxy)propoxy)diphenylsilane
EINECS	Contact for details

Quality Control

Our 3-((tert-Butyldiphenylsilyl)Oxy)-2,2-Difluoropropyl Trifluoromethanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹⁹F, ¹³C), and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development through to scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.