Description

6-(2,2,2-Trifluoroethoxy)Pyridine-3-Carbonitrile is a high-value pyridine derivative and a key fluorinated building block in advanced organic synthesis. Its core value lies in the unique combination of the pyridine ring, a nitrile group, and a trifluoroethoxy moiety, enabling precise molecular modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring fluorinated aromatic components.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-(2,2,2-Trifluoroethoxy)Pyridine-3-Carbonitrile
CAS No.	159981-18-7
Molecular Formula	C8H5F3N2O
Molecular Weight	202.13 g/mol
Synonyms	3-Cyano-6-(2,2,2-trifluoroethoxy)pyridine; 6-(2,2,2-Trifluoroethoxy)nicotinonitrile; 2,2,2-Trifluoroethyl 3-cyanopyridin-6-yl ether; 5-Cyano-2-(2,2,2-trifluoroethoxy)pyridine; Pyridine-3-carbonitrile, 6-(2,2,2-trifluoroethoxy)-; 6-(Trifluoroethoxy)pyridine-3-carbonitrile; 6-(β,β,β-Trifluoroethoxy)nicotinonitrile; 3-Cyano-6-(trifluoroethoxy)pyridine
EINECS	Contact for details

Quality Control

Our 6-(2,2,2-Trifluoroethoxy)Pyridine-3-Carbonitrile is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.