Description

17-o-((2-(3-(4-Azido-3-Iodophenyl)Propionamido)Ethyl)Carbamyl)Estradiol-3-n-Bis(Chloroethyl)Carbamate is a sophisticated synthetic steroid derivative designed for advanced research applications. This compound matters for its unique bifunctional structure, which incorporates a photoactivatable azide group and a nitrogen mustard moiety, enabling targeted cross-linking and alkylation studies. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel targeted therapies, particularly in oncology and endocrinology.

Application

• Research Tool for Targeted Drug Delivery: Used as a model compound in the development of estrogen receptor-targeted chemotherapeutic agents.
• Photoaffinity Labeling Studies: The aryl azide group allows for covalent cross-linking to biological targets upon UV irradiation, useful for identifying drug-protein interactions.
• Mechanistic Biochemistry Research: Employed to study the mechanisms of action of bifunctional alkylating agents and their site-specific effects.
• Prototype for Novel Anti-Cancer Agents: Serves as a key intermediate or reference standard in the synthesis and evaluation of new hormone-conjugated chemotherapeutics.
• Academic and Pharmaceutical R&D: Fundamental research into steroid-drug conjugates and their pharmacokinetic and pharmacodynamic properties.

Basic Information

Item	Detail
Product Name	17-o-((2-(3-(4-Azido-3-Iodophenyl)Propionamido)Ethyl)Carbamyl)Estradiol-3-n-Bis(Chloroethyl)Carbamate
CAS No.	159899-37-3
Molecular Formula	C38H43Cl2IN5O6
Molecular Weight	887.59 g/mol
Synonyms	Estradiol-3-n-bis(2-chloroethyl)carbamate-17-(2-(3-(4-azido-3-iodobenzamido)ethyl)carbamate); 17β-Estradiol 3-[N,N-bis(2-chloroethyl)carbamate] 17-[2-(3-(4-azido-3-iodophenyl)propanamido)ethylcarbamate]; 4-Azido-3-iodo-N-[2-[[(17β)-3-(bis(2-chloroethyl)carbamoyl)oxyestra-1,3,5(10)-trien-17-yl]oxy]-2-oxoethyl]benzamide; Estradiol Mustard Azido Iodide Derivative; Targeted Estrogen-Nitrogen Mustard Conjugate; Photoactivatable Estradiol Chemotherapeutic Agent
EINECS	Contact for details

Quality Control

Our 17-o-((2-(3-(4-Azido-3-Iodophenyl)Propionamido)Ethyl)Carbamyl)Estradiol-3-n-Bis(Chloroethyl)Carbamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. Due to its hygroscopic and light-sensitive nature, the container should be allowed to reach room temperature before opening to minimize moisture uptake and exposure to light. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.