Description

Azetidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, protected azetidine derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is essential for the efficient construction of complex molecular architectures, particularly in the development of novel pharmaceuticals and bioactive compounds. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and asymmetric synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of β-lactam antibiotics, protease inhibitors, and other active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in the design and construction of novel drug candidates, particularly those targeting neurological and metabolic diseases.
• Peptidomimetics: Serves as a constrained, non-proteinogenic amino acid analog for creating stable peptide mimics with enhanced biological activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective reactions to introduce the azetidine ring system.
• Agrochemical Development: Utilized in the research and synthesis of new generation herbicides and plant growth regulators.
• Ligand and Catalyst Development: Acts as a precursor for nitrogen-containing ligands used in transition metal catalysis.

Basic Information

Product Name	Azetidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	159749-28-7
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	1-(tert-Butoxycarbonyl)azetidine-2-carboxylic Acid; 1-Boc-azetidine-2-carboxylic Acid; Boc-Aze-OH; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]azetidine-2-carboxylic Acid; Azetidine-2-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-; 1-N-Boc-azetidine-2-carboxylic Acid; tert-Butyl azetidine-1,2-dicarboxylate (2-carboxylic acid); Aze(Boc)-OH
EINECS	Contact for details

Quality Control

Our Azetidine-1,2-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.