Description

Benzyl Spiro[Indoline-3,4'-Piperidine]-1-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 159635-46-8. This compound is a critical building block in modern medicinal chemistry, valued for its spirocyclic indoline-piperidine scaffold which is integral to developing novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis and development of new therapeutic agents, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Used in the research of potential therapeutics for neurological disorders due to its privileged heterocyclic structure.
• Oncological Research: Employed as a building block for novel small-molecule inhibitors and targeted cancer therapies.
• Chemical Biology Probes: Utilized in the development of molecular probes to study biological pathways and protein functions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs for bespoke chemical synthesis projects.

Basic Information

Product Name	Benzyl Spiro[Indoline-3,4'-Piperidine]-1-Carboxylate Hydrochloride
CAS No.	159635-46-8
Molecular Formula	C21H22N2O2 • HCl
Molecular Weight	370.88 g/mol (Free base: 334.42 g/mol)
Synonyms	1-[(Benzyloxy)carbonyl]spiro[indoline-3,4'-piperidine] hydrochloride; Spiro[indoline-3,4'-piperidine]-1-carboxylic acid benzyl ester hydrochloride; 1-CBz-Spiro[indoline-3,4'-piperidine] HCl; Benzyl 1-azaspiro[4.5]decane-8-carboxylate hydrochloride (related core); 1-N-Carbobenzyloxyspiro[indoline-3,4'-piperidine] hydrochloride
EINECS	Contact for details

Quality Control

Our Benzyl Spiro[Indoline-3,4'-Piperidine]-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.