Description

Spiro[1H-Isoindole-1,4'-Piperidin]-3(2H)-One, 2-Methyl- is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in synthetic organic chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially those targeting neurological receptors.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Synthesis: Serves as a versatile precursor for constructing spirocyclic and heterocyclic frameworks in organic synthesis.
• Reference Standard: Employed as an analytical standard for quality control and method development in API manufacturing.
• Academic Research: Utilized in university and institutional labs for studying novel synthetic methodologies and reaction mechanisms.

Basic Information

Product Name	Spiro[1H-Isoindole-1,4'-Piperidin]-3(2H)-One, 2-Methyl-
CAS No.	159635-27-5
Molecular Formula	C13H16N2O
Molecular Weight	216.28 g/mol
Synonyms	2-Methylspiro[isoindole-1,4'-piperidin]-3-one; 2-Methyl-1,4-dihydrospiro[isoindole-1,4'-piperidin]-3-one; 2-Methyl-2,3-dihydro-1H-spiro[isoindole-1,4'-piperidin]-3-one; 2-Methylspiro[1H-isoindole-1,4'-piperidin]-3(2H)-one; Spiro[1H-isoindole-1,4'-piperidine]-3(2H)-one, 2-methyl-; 159635-27-5
EINECS	Contact for details

Quality Control

Our Spiro[1H-Isoindole-1,4'-Piperidin]-3(2H)-One, 2-Methyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.