Description

Fmoc-D-Phe-Opfp CAS NO 159505-85-8 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and efficient incorporation of D-phenylalanine into complex peptide sequences. It is an essential reagent for pharmaceutical R&D, biotechnology, and academic research focused on developing novel therapeutic peptides, peptidomimetics, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential assembly of peptides using Fmoc-chemistry protocols.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Labeling: Facilitates the site-specific introduction of D-phenylalanine residues into proteins or other biomolecules.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Institutional Research: Fundamental tool for studying peptide structure-activity relationships and chiral chemistry.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of non-natural or D-amino acid-containing peptides.

Basic Information

Product Name	Fmoc-D-Phe-Opfp
CAS No.	159505-85-8
Molecular Formula	C31H20F5NO5
Molecular Weight	581.49 g/mol
Synonyms	Fmoc-D-phenylalanine pentafluorophenyl ester; N-(9-Fluorenylmethoxycarbonyl)-D-phenylalanine pentafluorophenyl ester; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid 2,3,4,5,6-pentafluorophenyl ester; Fmoc-D-Phe-OPfp; Fmoc-D-Phenylalanine-OPfp ester; Fmoc-D-Phe-OPh(2,3,4,5,6-F5); OPfp ester of Fmoc-D-Phenylalanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-D-Phe-Opfp is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high chemical purity and chiral integrity, critical for sensitive peptide synthesis applications. A detailed Certificate of Analysis (COA) providing results for identity, purity (HPLC), chiral purity, and moisture content is supplied with each shipment to guarantee batch-to-batch consistency and reliable performance in your processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.