Description

tert-Butyl 4-Bromo-5,6-dihydropyridine-1(2H)-carboxylate is a high-value, protected heterocyclic building block essential for modern synthetic chemistry. Its core value lies in providing a reactive bromine handle on a partially saturated pyridine scaffold, enabling precise functionalization for complex molecule assembly. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of piperidine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, where the dihydropyridine core is a valuable structural motif.
• Cross-Coupling Reactions: Serves as a crucial electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi, Stille) to form carbon-carbon bonds.
• Nucleophilic Substitution: The bromine atom is readily displaced by various nucleophiles, facilitating the introduction of amines, alkoxides, and other functional groups.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry programs.
• Material Science Research: Acts as a monomer or functionalizing agent in the creation of specialized polymers and organic electronic materials.

Basic Information

Product Name	tert-Butyl 4-Bromo-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.	159503-91-0
Molecular Formula	C10H16BrNO2
Molecular Weight	262.14 g/mol
Synonyms	1-Boc-4-bromo-1,2,3,6-tetrahydropyridine; 4-Bromo-1,2,3,6-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 4-Bromo-1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridine; 4-Bromo-N-Boc-1,2,3,6-tetrahydropyridine; tert-Butyl 4-bromo-3,6-dihydro-2H-pyridine-1-carboxylate; 1,2,3,6-Tetrahydro-4-bromopyridine-1-carboxylic acid tert-butyl ester; 4-Bromo-1,2,3,6-tetrahydropyridine, 1-Boc protected; 4-Bromo-N-Boc-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Bromo-5,6-dihydropyridine-1(2H)-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay	≥97.0%
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.