Description

(2S,3S)-2-Azido-3-Methylpentanoic Acid CAS NO 159407-40-6 is a high-purity, non-natural amino acid derivative featuring a strategically positioned azido functional group. This compound serves as a critical chiral building block and click chemistry reagent for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced drug discovery, peptide mimetic development, and chemical biology studies.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and peptidomimetics.
• Click Chemistry Reagent: The azide group enables efficient, selective Huisgen 1,3-dipolar cycloaddition reactions with alkynes for bioconjugation and polymer modification.
• Peptide Research: Used to incorporate non-natural amino acid residues into peptide chains to study structure-activity relationships and enhance metabolic stability.
• Chemical Biology Probes: Facilitates the labeling and tracking of biomolecules in cellular systems for target identification and validation studies.
• Agrochemical Synthesis: Serves as a precursor for developing chiral compounds with potential herbicidal or insecticidal activity.
• Material Science: Employed in the creation of functionalized polymers and smart materials with tailored properties.

Basic Information

Product Name	(2S,3S)-2-Azido-3-Methylpentanoic Acid
CAS No.	159407-40-6
Molecular Formula	C6H11N3O2
Molecular Weight	157.17 g/mol
Synonyms	(2S,3S)-2-Azido-3-methylpentanoic acid; (2S,3S)-2-Azido-3-methylvaleric acid; L-threo-2-Azido-3-methylpentanoic acid; 2-Azido-3-methylpentanoic acid, (2S,3S)-; Azidomethylvaleric acid; 159407-40-6; (2S,3S)-α-Azido-β-methylvaleric acid
EINECS	Contact for details

Quality Control

Our (2S,3S)-2-Azido-3-Methylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.