Description

Cyclohexanecarboxylic Acid, 3-Amino-2-Hydroxy-, Ethyl Ester, (1Alpha,2Alpha,3Alpha)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its unique structure, featuring amino, hydroxy, and ester functional groups on a cyclohexane scaffold, makes it a versatile intermediate for constructing complex molecules with precise three-dimensional architecture. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals. The CAS number for this compound is 159406-07-2.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly for central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Used in the creation of advanced, stereoselective pesticides and herbicides where specific chirality is crucial for biological activity.
• Catalyst and Ligand Development: Serves as a precursor for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Employed to introduce constrained cyclohexane motifs into peptide backbones, enhancing metabolic stability and bioavailability.
• Academic & Industrial R&D: A valuable tool for chemists exploring new synthetic methodologies and constructing complex natural product analogs.
• Fine Chemical Production: Integral in the multi-step synthesis of high-value, specialty chemicals for electronics and material science applications.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 3-Amino-2-Hydroxy-, Ethyl Ester, (1Alpha,2Alpha,3Alpha)- (9Ci)
CAS No.	159406-07-2
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	(1α,2α,3α)-3-Amino-2-hydroxycyclohexanecarboxylic acid ethyl ester; Ethyl (1α,2α,3α)-3-amino-2-hydroxycyclohexanecarboxylate; cis-3-Amino-2-hydroxycyclohexanecarboxylic acid ethyl ester; (1R,2R,3R)-3-Amino-2-hydroxycyclohexanecarboxylic acid ethyl ester; 3-Amino-2-hydroxycyclohexanecarboxylic acid ethyl ester (cis isomer); AHCEE; Chiral cyclohexane amino ester.
EINECS	Contact for details

Quality Control

Every batch of Cyclohexanecarboxylic Acid, 3-Amino-2-Hydroxy-, Ethyl Ester, (1Alpha,2Alpha,3Alpha)- (9Ci) is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles are available for each lot. Our quality protocols are designed to support cGMP-compliant workflows for pharmaceutical customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.