Description

Decanedioic Acid, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester is a high-purity chemical intermediate featuring a reactive N-hydroxysuccinimide (NHS) ester group linked to a sebacic acid backbone. This molecular structure makes it a critical reagent for the efficient and selective conjugation of amine-containing compounds, enabling the formation of stable amide bonds under mild conditions. It is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors who require reliable, high-yield coupling agents for peptide synthesis, protein labeling, and polymer functionalization.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and prodrugs via amide bond formation.
• Bioconjugation Reagent: Used for labeling antibodies, proteins, and peptides with fluorescent dyes, drugs, or other biomolecules for diagnostics and targeted therapies.
• Polymer Modification: Functionalizes polymers and dendrimers by introducing amine-reactive sites to create smart materials, hydrogels, and drug delivery systems.
• Crosslinking Agent: Employed in the preparation of crosslinked biomaterials, coatings, and adhesives that require specific mechanical or chemical properties.
• Peptide Synthesis: Serves as an efficient coupling agent in solid-phase and solution-phase peptide synthesis to form peptide bonds.
• Surface Functionalization: Used to modify the surface of nanoparticles, chips, and other substrates with amine-reactive groups for biosensor and microarray applications.

Basic Information

Product Name	Decanedioic Acid, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester
CAS No.	159350-38-6
Molecular Formula	C₁₄H₂₁NO₆
Molecular Weight	299.32 g/mol
Synonyms	Sebacic Acid N-Hydroxysuccinimide Ester; NHS-Sebacate; Sebacoyl Bis(N-hydroxysuccinimide) Ester; N,N'-Disuccinimidyl Sebacate; DSC (Disuccinimidyl Carbonate) derivative of Sebacic Acid; 1,10-Bis(2,5-dioxopyrrolidin-1-yl)oxy)-1,10-dioxodecane; Sebacic Acid NHS Ester; Succinimidyl Sebacate
EINECS	Contact for details

Quality Control

Our Decanedioic Acid, 1-(2,5-Dioxo-1-Pyrrolidinyl) Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets exacting standards for sensitive applications like bioconjugation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis of the active ester group. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	≤ 10 ppm
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.