Description

Homopravastatin CAS NO 159345-66-1 is a key pharmaceutical intermediate and a structural analog of the cholesterol-lowering agent Pravastatin. This compound is of significant value in the research and development of novel HMG-CoA reductase inhibitors and other therapeutic agents targeting lipid metabolism. It is primarily required by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers engaged in the synthesis of advanced statin derivatives and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the synthesis of novel statin analogs and other cardiovascular drugs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new HMG-CoA reductase inhibitors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of pravastatin-related compounds.
• Biochemical Research: Utilized in enzymatic and metabolic studies to investigate the mechanism of cholesterol biosynthesis inhibition.
• Custom Synthesis: Building block for the contract manufacturing of specialized, non-commercial drug candidates for clinical trials.

Basic Information

Product Name	Homopravastatin
CAS No.	159345-66-1
Molecular Formula	C₂₄H₃₄O₆
Molecular Weight	418.53 g/mol
Synonyms	Pravastatin Impurity C; (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-Hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid; 1-Naphthaleneheptanoic acid, 1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1α(2S*,4S*),2β,6β,8β(R*),8aβ))-; Pravastatin EP Impurity C; Pravastatin Related Compound C; Homopravastatin Sodium; SQ-31906
EINECS	Contact for details

Quality Control

Our Homopravastatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.