Description

(R)-3-(tert-Butyldimethylsilyloxy) Pyrrolidine is a high-value, chiral pyrrolidine derivative featuring a tert-butyldimethylsilyl (TBDMS) protecting group on the hydroxyl moiety. This compound serves as a critical chiral building block and intermediate in sophisticated organic synthesis, enabling the stereoselective construction of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereochemistry is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of drug candidates, particularly for neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the research and development of chiral pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Natural Product Synthesis: Employed in the total synthesis of complex natural products containing pyrrolidine or related heterocyclic scaffolds.
• Peptidomimetic Research: Acts as a constrained, chiral scaffold for designing and synthesizing peptide mimics with improved stability and bioavailability.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(R)-3-(tert-Butyldimethylsilyloxy) Pyrrolidine
CAS No.	159330-31-1
Molecular Formula	C10H23NOSi
Molecular Weight	201.38 g/mol
Synonyms	(R)-3-[(tert-Butyldimethylsilyl)oxy]pyrrolidine; (3R)-3-[(tert-Butyldimethylsilyl)oxy]pyrrolidine; (R)-3-(TBDMSO)pyrrolidine; (R)-N-Boc-3-(tert-butyldimethylsilyloxy)pyrrolidine (common precursor); Pyrrolidine, 3-[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3R)-; (R)-3-Hydroxypyrrolidine TBDMS ether; (R)-3-O-TBDMS-pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-3-(tert-Butyldimethylsilyloxy) Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.