Description

1,2-Di-o-Acetyl-5-o-Benzoyl-3-Deoxy-3-Fluoro-D-Xylofuranose is a high-purity fluorinated carbohydrate derivative, serving as a critical chiral building block and synthetic intermediate. Its value lies in enabling the precise introduction of fluorine atoms into nucleoside and carbohydrate scaffolds, a key strategy for modulating the biological activity and metabolic stability of pharmaceutical compounds. This product is essential for researchers and manufacturers in pharmaceutical development, particularly for the synthesis of antiviral and anticancer nucleoside analogs, as well as for advanced organic synthesis and medicinal chemistry research.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated nucleoside analogs with potential antiviral (e.g., anti-HIV, anti-hepatitis) and anticancer activities.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies to explore the impact of fluorination on drug potency, selectivity, and pharmacokinetics.
• Carbohydrate Chemistry: Serves as a specialized substrate for developing novel glycosylation methodologies and synthesizing complex, fluorinated oligosaccharides.
• Antiviral Drug Development: Integral to the research and production pipeline for next-generation antiviral therapeutics that incorporate modified sugar moieties.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes for studying enzyme mechanisms and biological pathways involving carbohydrates.
• Process Chemistry & Scale-up: Supplied for process optimization and pilot-scale synthesis campaigns in GMP or non-GMP environments.

Basic Information

Product Name	1,2-Di-o-Acetyl-5-o-Benzoyl-3-Deoxy-3-Fluoro-D-Xylofuranose
CAS No.	159099-24-8
Molecular Formula	C₁₆H₁₇FO₇
Molecular Weight	340.30 g/mol
Synonyms	3-Deoxy-3-fluoro-1,2-di-O-acetyl-5-O-benzoyl-D-xylofuranose; 5-O-Benzoyl-3-deoxy-3-fluoro-1,2-di-O-acetyl-D-xylofuranose; 1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-xylofuranose; 3-Fluoro-3-deoxy-1,2-di-O-acetyl-5-O-benzoyl-D-xylofuranose; Fluorinated D-xylofuranose derivative; Benzoyl-protected fluoroxylofuranose; CAS 159099-24-8
EINECS	Contact for details

Quality Control

Our 1,2-Di-o-Acetyl-5-o-Benzoyl-3-Deoxy-3-Fluoro-D-Xylofuranose is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development from research to commercial scale with quality standards that can align with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.