Description

L-Threo-Pentonic Acid, 2-Deoxy-3,5-Bis-o-(Phenylmethyl)-, .Gamma.-Lactone is a high-purity, protected sugar lactone derivative serving as a critical chiral building block and synthetic intermediate. This compound is essential for the controlled synthesis of complex nucleoside analogs, antiviral agents, and other biologically active molecules where stereochemical integrity is paramount. It is primarily utilized by pharmaceutical R&D departments, fine chemical manufacturers, and academic research institutions focused on medicinal chemistry and carbohydrate chemistry.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Carbohydrate Chemistry Research: Used in the study and development of modified sugars and glycomimetics with specific biological activities.
• Fine Chemical Synthesis: Serves as a protected synthon for constructing complex molecular architectures requiring precise stereocontrol.
• Bioconjugate Development: Potential use in creating labeled or modified biomolecules for diagnostic or therapeutic applications.
• Academic & Process Chemistry: Employed in method development, asymmetric synthesis routes, and scaling up synthetic pathways.

Basic Information

Product Name	L-Threo-Pentonic Acid, 2-Deoxy-3,5-Bis-o-(Phenylmethyl)-, .Gamma.-Lactone
CAS No.	158976-98-8
Molecular Formula	C19H20O4
Molecular Weight	312.36 g/mol
Synonyms	2-Deoxy-3,5-di-O-benzyl-L-threo-pentono-1,4-lactone; 3,5-Di-O-benzyl-2-deoxy-L-threo-pentono-1,4-lactone; 1,4-Lactone of 2-deoxy-3,5-di-O-benzyl-L-threo-pentonic acid; Protected L-threo-pentono-1,4-lactone derivative; Benzyl-protected deoxypentono lactone; L-Threo configured sugar lactone; Chiral pentono lactone intermediate.
EINECS	Contact for details

Quality Control

Our production of L-Threo-Pentonic Acid, 2-Deoxy-3,5-Bis-o-(Phenylmethyl)-, .Gamma.-Lactone adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure consistent stereochemical integrity and high chemical purity. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; ensure the container is sealed under an inert atmosphere after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.