Description

L-Norvaline T-Butyl Ester is a protected amino acid derivative, specifically the tert-butyl ester of L-norvaline, serving as a crucial chiral building block in organic synthesis. Its primary value lies in providing a sterically hindered, acid-labile protecting group for the carboxylic acid moiety, enabling selective deprotection in complex multi-step reactions. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of therapeutic peptides and small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the L-norvaline residue with a protected carboxyl group.
• Protease Inhibitor Development: Serves as a building block for creating inhibitors that target specific enzymes.
• Bioconjugation & Linker Chemistry: Utilized in the design of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted therapies.
• Chemical Biology Research: Employed in the synthesis of modified amino acids and probes for studying protein function and interactions.
• Agrochemical Synthesis: Acts as an intermediate in the development of chiral, biologically active compounds for crop protection.

Basic Information

Product Name	L-Norvaline T-Butyl Ester
CAS No.	158741-16-3
Molecular Formula	C9H19NO2
Molecular Weight	173.25 g/mol
Synonyms	(S)-2-Amino-pentanoic acid tert-butyl ester; L-2-Aminovaleric acid tert-butyl ester; tert-Butyl L-norvalinate; (S)-tert-Butyl 2-aminopentanoate; Norvaline tert-butyl ester; Boc-Norvaline-OtBu (common error, but often searched); H-Norval-OtBu; (S)-tert-Butyl 2-aminovalerate
EINECS	Contact for details

Quality Control

Our L-Norvaline T-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material to meet specific customer requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.