Description

(2R)-L-γ-Glutamyl-3-((2-((Bis(Bis(2-Chloroethyl)Amino)Phosphinyl)Oxy) Ethyl)Sulfonyl)- L-Alanyl-2-Phenylglycine is a sophisticated synthetic peptide derivative designed for advanced research and development. This compound is of significant interest in the field of targeted therapeutics due to its unique structure, which combines a peptide backbone with a nitrogen mustard phosphoramidate moiety. It is primarily utilized by pharmaceutical researchers and biotechnology companies engaged in the development of novel prodrugs and targeted cancer therapies.

Application

• Prodrug Development: Serves as a key intermediate or model compound in the research of enzyme-activated prodrug systems for targeted drug delivery.
• Anticancer Agent Research: Investigated for its potential as a cytotoxic agent in experimental oncology, leveraging its nitrogen mustard component.
• Bioconjugation Studies: Used in studies focusing on linking therapeutic payloads to targeting vectors like antibodies or peptides.
• Enzyme Substrate Profiling: Acts as a specific substrate for studying the activity of enzymes such as γ-glutamyl transpeptidase (GGT) in biochemical assays.
• Chemical Biology Tool: Employed in research to understand cell-specific activation mechanisms and to design new therapeutic modalities.
• Preclinical Pharmaceutical Development: Used in the synthesis and evaluation of novel drug candidates in early-stage R&D pipelines.

Basic Information

Product Name	(2R)-L-γ-Glutamyl-3-((2-((Bis(Bis(2-Chloroethyl)Amino)Phosphinyl)Oxy) Ethyl)Sulfonyl)- L-Alanyl-2-Phenylglycine
CAS No.	158382-37-7
Molecular Formula	C24H38Cl4N5O11PS
Molecular Weight	792.44 g/mol
Synonyms	L-γ-Glutamyl-3-((2-((Bis(Bis(2-Chloroethyl)Amino)Phosphinyl)Oxy)Ethyl)Sulfonyl)-L-Alanyl-2-Phenylglycine; GGT-Activated Nitrogen Mustard Prodrug; 4-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-5-[[(2R)-5-amino-1-[[(2R)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic Acid (related structural name); Phosphorodiamidic acid, N,N-bis[2-(bis(2-chloroethyl)amino)ethyl]-, 2-[[(1S)-1-[[(2S)-1-[[(4S)-4-amino-4-carboxy-1-oxobutyl]amino]-3-(phenylmethoxy)-1-oxopropan-2-yl]amino]-1-oxo-3-(phenylmethoxy)propyl]amino]ethyl ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.