Description

Nir-667 n-Succinimidyl Ester is a high-purity, reactive chemical intermediate designed for advanced bioconjugation and labeling applications. This compound is critical for researchers and manufacturers who require reliable, site-specific coupling of probes, tags, or other molecules to primary amines under mild aqueous conditions. It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic sectors for developing targeted therapeutics, imaging agents, and assay components.

Application

• Bioconjugation Reagent: For the covalent attachment of fluorescent dyes, biotin, peptides, or drug molecules to antibodies, proteins, and other amine-containing biomolecules.
• Probe Synthesis: A key building block in the synthesis of near-infrared (NIR) fluorescent probes and imaging agents for in vivo and in vitro diagnostics.
• ADC (Antibody-Drug Conjugate) Development: Used to create stable linker-payload constructs for targeted cancer therapies.
• Surface Functionalization: For modifying nanoparticles, microspheres, biosensor chips, and other solid supports with amine-reactive groups.
• Cross-linking Agent: In the preparation of cross-linked polymers, hydrogels, or protein complexes for research and material science.
• Diagnostic Kit Manufacturing: As a critical reagent in the production of enzyme conjugates and labeled antigens/antibodies for ELISA and lateral flow assays.

Basic Information

Product Name	Nir-667 n-Succinimidyl Ester
CAS No.	158358-57-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	NIR-667 NHS Ester; Nir667 Succinimidyl Ester; Nir 667 SE; Nir667-NHS; Succinimidyl Nir-667 ester; Amine-reactive Nir-667 dye; Nir667 fluorescent label NHS ester; Contact for details
EINECS	Contact for details

Quality Control

Every batch of Nir-667 n-Succinimidyl Ester is manufactured and tested under strict quality management systems to ensure consistent high purity and performance. Our products undergo rigorous quality testing, including chromatographic purity analysis and functional group verification, to ensure compliance with industry standards. Certificates of Analysis (COA) documenting identity, purity, and suitability for bioconjugation are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Dark green to blue solid or powder
Identification (HPLC/UV-Vis)	Conforms
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, acetonitrile
Extinction Coefficient	Contact for details
Functional Group Verification (NMR/IR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.