Description

1-Benzyl 4-Methyl (2S)-2-{[(tert-Butoxy)Carbonyl]Amino}Butanedioate is a high-purity, chiral amino acid derivative widely used as a critical building block in advanced organic synthesis. Its value lies in providing a protected aspartic acid moiety with orthogonal protecting groups, enabling precise and sequential peptide coupling strategies. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptide-based therapeutics, protease inhibitors, and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide drugs and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate protected aspartic acid residues.
• Protease Inhibitor Development: Serves as a core scaffold in the research and production of inhibitors for enzymes like HIV protease.
• Bioconjugation: Employed in the preparation of peptide-protein conjugates for diagnostic and therapeutic applications.
• Chemical Biology Research: Utilized as a tool compound for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis: A starting material for the bespoke synthesis of complex, non-natural amino acids and small molecule libraries.

Basic Information

Product Name	1-Benzyl 4-Methyl (2S)-2-{[(tert-Butoxy)Carbonyl]Amino}Butanedioate
CAS No.	158201-15-1
Molecular Formula	C17H23NO6
Molecular Weight	337.37 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]butanedioic acid 1-benzyl 4-methyl ester; Boc-Asp(OBzl)-OMe; N-Boc-L-aspartic acid 4-benzyl ester 1-methyl ester; Nα-Boc-L-aspartic acid β-benzyl ester α-methyl ester; Methyl N-Boc-L-aspartate 4-benzyl ester; 1-Benzyl 4-methyl (2S)-2-[(tert-butoxycarbonyl)amino]succinate; Boc-Asp(OBn)-OMe; L-Aspartic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-benzyl 4-methyl ester
EINECS	Contact for details

Quality Control

Our 1-Benzyl 4-Methyl (2S)-2-{[(tert-Butoxy)Carbonyl]Amino}Butanedioate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with the highest standards for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.