Description

Bromo-Peg1-Ch2Co2Tbu is a specialized bifunctional PEG linker featuring a bromoalkyl group and a tert-butyl ester-protected carboxylic acid. This compound is engineered to provide a versatile and reactive handle for bioconjugation, polymer modification, and the synthesis of complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise and reliable building blocks for drug delivery systems, diagnostic probes, and functional polymers.

Application

• Bioconjugation Reagent: Used to attach therapeutic molecules, dyes, or targeting ligands to peptides, proteins, or antibodies via the reactive bromo group.
• Polymer Functionalization: Serves as a key monomer or end-capping agent for synthesizing functionalized polyethylene glycol (PEG) polymers with tailored properties.
• Prodrug Synthesis: The protected carboxylic acid group allows for the creation of cleavable linkers in prodrug design, enabling controlled drug release.
• Surface Modification: Utilized to introduce PEG chains onto nanoparticles or solid surfaces to improve biocompatibility and reduce non-specific binding.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker for coupling different biomolecules or materials in diagnostic assay development.
• Intermediate for Further Derivatization: The tert-butyl ester can be readily deprotected to yield a free carboxylic acid for subsequent amide bond formation or other coupling reactions.

Basic Information

Product Name	Bromo-Peg1-Ch2Co2Tbu
CAS No.	157759-50-7
Molecular Formula	C9H17BrO4
Molecular Weight	269.14 g/mol
Synonyms	2-(2-Bromoethoxy)acetic acid tert-butyl ester; tert-Butyl 2-(2-bromoethoxy)acetate; Bromo-PEG1-t-butyl ester; 2-(2-Bromoethoxy)acetic acid 1,1-dimethylethyl ester; Bromoethoxyacetic acid tert-butyl ester; Bifunctional PEG linker, Bromo-PEG1-COOtBu; 157759-50-7; Bromo-PEG1-tBu ester
EINECS	Contact for details

Quality Control

Our Bromo-Peg1-Ch2Co2Tbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. Due to its highly volatile nature, ensure containers are sealed when not in use and stored away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.