Description

3-Hydroxy-13-Amino-13,17-Seco-5Alpha-Androstan-17-Oic-13,17-Lactam 2-N,n-Bis(2-Chloroethyl)Aminobenzoate is a complex, nitrogen-mustard conjugated steroidal lactam derivative, representing a sophisticated chemical entity for advanced research and development. This compound matters for its potential as a key synthetic intermediate or a pharmacophore in the development of targeted therapeutic agents, particularly in oncology and endocrinology. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on novel drug discovery and high-value fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel steroidal-based drug candidates, particularly those with alkylating properties for targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe in studies investigating hormone receptor interactions, enzyme inhibition, and structure-activity relationships (SAR) of modified steroids.
• Medicinal Chemistry: Acts as a core scaffold for the design and development of new chemical entities with potential anti-cancer, anti-inflammatory, or hormonal activity.
• Advanced Organic Synthesis: Employed in complex multi-step syntheses requiring high-purity, specialized steroidal frameworks with reactive functional groups for further derivatization.
• Preclinical Development: Utilized in the production of compounds for in vitro and in vivo pharmacological and toxicological evaluation during early-stage drug discovery.

Basic Information

Product Name	3-Hydroxy-13-Amino-13,17-Seco-5Alpha-Androstan-17-Oic-13,17-Lactam 2-N,n-Bis(2-Chloroethyl)Aminobenzoate
CAS No.	157757-66-9
Molecular Formula	C32H44Cl2N2O4
Molecular Weight	615.61 g/mol
Synonyms	13-Amino-3-hydroxy-13,17-seco-5α-androstan-17-oic acid 13,17-lactam 2-[bis(2-chloroethyl)amino]benzoate; 2-[Bis(2-chloroethyl)amino]benzoic acid 13-amino-3-hydroxy-13,17-seco-5α-androstan-17-oate 13,17-lactam; Nitrogen mustard steroidal lactam conjugate; 157757-66-9; 5α-Androstane-17-carboxylic acid, 13-amino-3-hydroxy-13,17-seco-, 13,17-lactam, 2-[bis(2-chloroethyl)amino]benzoate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for research reproducibility. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.