Description

5-Bromo-5-Deoxy-2-C-Methyl-2,3-o-(1-Methylethylidene)-D-Ribonic-γ-Lactone is a specialized, high-value brominated sugar derivative and a key chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex nucleoside analogs and other bioactive molecules, offering precise stereochemical control. It is primarily needed by research and development chemists in the pharmaceutical and biotechnology sectors for the synthesis of potential antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery programs.
• Chiral Building Block: Used in asymmetric synthesis to introduce complex sugar moieties with defined stereochemistry into target molecules.
• Glycochemistry Research: Serves as a valuable substrate for studying glycosylation reactions and modifying carbohydrate structures.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new therapeutic candidates with improved efficacy and selectivity.
• Process Chemistry Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific brominated lactone scaffold.
• Academic & Contract Research: A key reagent for universities and CROs conducting fundamental research in organic synthesis and chemical biology.

Basic Information

Item	Details
Product Name	5-Bromo-5-Deoxy-2-C-Methyl-2,3-o-(1-Methylethylidene)-D-Ribonic-γ-Lactone
CAS No.	157666-07-4
Molecular Formula	C9H13BrO4
Molecular Weight	265.10 g/mol
Synonyms	5-Bromo-5-deoxy-2-C-methyl-2,3-O-isopropylidene-D-ribono-1,4-lactone; 5-Bromo-5-deoxy-2-C-methyl-2,3-O-(1-methylethylidene)-D-ribono-γ-lactone; 2,3-O-Isopropylidene-5-bromo-5-deoxy-2-C-methyl-D-ribono-1,4-lactone; 5-Bromo-2,3-O-isopropylidene-5-deoxy-2-C-methyl-D-ribono-γ-lactone; Brominated Isopropylidene Ribonolactone Derivative; (3aR,5R,6S,6aR)-5-Bromo-6-methyl-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-4(3aH)-one
EINECS	Contact for details

Quality Control

Our 5-Bromo-5-Deoxy-2-C-Methyl-2,3-o-(1-Methylethylidene)-D-Ribonic-γ-Lactone is produced under strict quality management systems to ensure batch-to-batch consistency for research and development. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.